Hepatic portal vein (HPV) injection is a method used to deliver substances directly into the liver via the portal circulation. The protocol involves anesthetizing the subject (e.g., mouse or rat), making a midline abdominal incision to expose the hepatic portal vein, carefully inserting a fine-gauge needle, and injecting the substance slowly to prevent vascular damage. After injection, the needle is withdrawn, and the incision is sutured. This method is commonly used in liver-targeted drug delivery, gene therapy, and metabolic studies.
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